Anne's known disorders are prosoapamnesia, dyslexia, involuntary emotional expression disorder, Stendhal syndrome, foreign accent syndrome, nocturnal lagophthalmos, a form of dystonia called 'backwards cheerleader syndrome,' and a condition where her left hand does what it wants.
In August 2018, NBC's option for a third season of Trial & Error lapsed, so Warner Bros. Television planned to shop the comedy to other outlets.
The character name "Dwayne Reed" is a pun on "Duane Reade," the ubiquitous New York drug store chain, while "Carol Anne Keane" plays on "Carolyn Keene," the nom de plume of the various authors who wrote the Nancy Drew mystery books.
The address of the Henderson home is 187, referring to the California Penal Code for murder.
John Lithgow's character name, Larry Henderson, refers to Harry and the Hendersons (1987) and Lithgow's character, George Henderson.