The song was written by Madonna as an anthemic, self-manifesto song which, although it appears to be about dance and sex, is a reference to Madonna's career spanning three decades in the music industry.
Musically, "Give It 2 Me" is an upbeat dance-pop song, featuring instrumentation from West African percussion and cowbells.
The song became Madonna's 39th number-one single on the Billboard Hot Dance Club Play chart.
It charted on the Billboard Hot 100 for one week, and reached a peak of 57 only, due to limited radio play.
The song topped the music charts in Hungary, the Netherlands and Spain, while it peaked within the top ten of the charts in many other nations, including Canada, Denmark and the United Kingdom.