While this episode contains the wedding day of Dr Natalie Manning and Dr Will Halstead, in real life Torrey DeVitto who portrays Natalie is actually dating Jesse Lee Soffer who portrays Det. Jay Halstead, Will's brother. Soffer and DeVitto announced they were dating in September 2018.
Brooke Smith, who plays Amber Young in this episode, played Dr Erika Hahn on Grey's Anatomy.