- She was at the bedside, with her son Wolfgang Van Halen, and Eddie's second wife (now widow) Janie Liszewski, when her ex-husband, Edward Van Halen died of throat cancer in Santa Monica on October 6, 2020.
- Cousin of Courteney Cox.
- Completed the Boston Marathon on April 19, 2010.
- Her father was of Italian descent and her mother was of mostly English, and some Irish, ancestry. Valerie was raised Catholic.
- Is a descendant of England's King Edward I, on her mother's side.
- Legally separated from Edward Van Halen in 2001, filed for divorce in December 2005, and finalized the divorce in December 2007.
- Turned down several feature film roles in the 1980s because of gratuitous nudity.
- She was awarded a Star on the Hollywood Walk of Fame for Television at 6912 Hollywood Boulevard in Hollywood, California on August 22, 2012.
- Ranked #29 on VH1's list of "100 Greatest Kid Stars".
- Acting mentor was Bonnie Franklin.
- Was considered for Lori Singer's role in Footloose (1984) and Meg Tilly's role in The Big Chill (1983).
- Mother, with Edward Van Halen, of son Wolfgang Van Halen, born on March 16, 1991, which was the same day country singer/actress Reba McEntire's seven band members died in a plane crash near San Diego, California.
- Best remembered by the public for her starring role as daughter Barbara Cooper Royer in One Day at a Time (1975).
- Tried out for the role of Iris Steensma in Taxi Driver (1976), but lost out to Jodie Foster.
- Was considered for the role of Jamie Buchman on Mad About You (1992) before Helen Hunt was hired.
- Friends with Jane Leeves and Faith Ford.
- Remains close to her former One Day at a Time (1975) co-star Glenn Scarpelli.
- Engaged to Tom Vitale after six years together [May 19, 2010].
- Raised in Claymont, Delaware.
- Inducted into the Hair Fan's Hall of Fame (2014).
- Daughter of Andrew Bertinelli and Nancy Bertinelli. Sister of Mark, Drew, David and Patrick Bertinelli.
- Was considered for the role of Chris Parker in Adventures in Babysitting (1987), which went to Elisabeth Shue.
- Born on the exact same date as Craig Sheffer.
- Ex-stepmother of Angela Vitale and Andie Vitale.
- Sister-in-law of Stacy Bertinelli.
- Her agent is Marc Schwartz.
- Ex-Aunt-in-law of David Vitale Jr. and Anthony Vitale.
- Her manager is Jack Grossbart.
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