- Donates time to the animal sanctuary Best Friends.
- She is of Russian Jewish and Polish Jewish descent.
- She enjoys writing, composing music and painting.
- Her father, Alvin Edelstein, was a pediatrician.
- Has three dogs: Shazam!, Leylo, and Banana.
- Lisa authored, composed and performed the musical "Positive Me," one of the earliest AIDS-related theater productions, at Ellen Stuart's La Mama in Manhattan.
- Lisa was raised in Wayne, NJ. She graduated from Wayne Valley High School, class of 1984.
- She began her professional acting career while studying theater at N.Y.U.
- Played a transsexual on Ally McBeal (1997), a sex-obsessed artist on Frasier (1993), and a high-priced call girl on The West Wing (1999).
- Speaks some Spanish.
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