Agent West is voiced by Michael Rosenbaum, who played the Flash/Wally West in the TV series Justice League (2001) and Justice League Unlimited (2004).
Although Zeta originally appeared in "Zeta", an episode of the TV series Batman Beyond (1999), he was given a redesigned appearance and a new voice actor for this spin-off TV series.
This is the only series in the DC Animated Universe in which the protagonist was not a character from DC Comics. Zeta made his first appearance in Zeta (2000).
The show staff has teased over the years that the hand seen reaching out of the water at the end of The Hologram Man (2002) belonged to Andrea Donoso, Eli Selig's assistant who would have been revealed to be a more advanced synthoid than Zeta.