The team shares stories of their defining moments. Pete has a hard time accepting the end of Warehouse 13. Claudia has a difficult time accepting her future role as the Warehouse caretaker.
Pete, Myka, and Claudia each travel to save a loved one who has fallen victim to an artifact, Mrs. Frederic and Steve head to the Vatican to investigate the Brotherhood, and Artie has an impossible showdown with Brother Adrian.
The evil alchemist Paracelsus is on the run, and Pete and Myka must stop him before he achieves immortality - or something worse. Myka fights what appears to be a losing battle against cancer, while Steve learns Artie's been keeping life-altering information from Claudia.
Mrs. Frederics explains the reason for MacPherson's break with the Warehouse program. Despite some extreme precautions he managed to get his hands on some artifacts that he plans to auction. But to Artie and the team it all sounds like a smoke screen for a more nefarious plan.
Warehouse 13 has been destroyed, Pandora's Box has been opened, and quite possibly the only hope left in the world lies in the use of a dangerous, evil artifact with the ability to turn back time.
It's nearly Christmas, and a brush with the upholstery brush of Philip Van Doren Stern bears Pete from his wonderful life into a world where he's never been born.