Professional, Vatican-funded vampire slayer Jack Crow (
James Woods) and his team are almost wiped out by master vampire Jan Valek (
Thomas Ian Griffith) after they make a successful raid on one of Valek's nests in New Mexico. Crow and his only surviving teammate Tony Montoya (
Daniel Baldwin) are subsequently ordered by Cardinal Alba (
Maximilian Schell) to rebuild their team and go after Valek, who is reportedly looking for an ancient relic, the black Bersier cross. Joined by an inexperienced priest, Father Adam Guiteau (
Tim Guinee), and an unlucky hooker named Katrina (
Sheryl Lee), who has just been bitten by Valek, the team sets out to find the cross first and destroy Valek. If they fail, vampires will soon be able to walk in daylight.