Randy comes to terms with his role in the COVID-19 outbreak as the pandemic presents challenges to the citizens of South Park. The kids happily return to school, but nothing resembles the normal they once knew.
The citizens of South ParQ are clamoring for the COVID-19 vaccine. A hilarious new militant group tries to stop the boys from getting their teacher vaccinated.
If Stan, Kyle and Cartman could just work together, they could go back in time to make sure Covid never happened and save Kenny's life. Traveling back to the past seems to be the easy answer until they meet Victor Chaos.